Reverse FX isn't just different; it's better. Everyone has a "different" supplement or a different spin on an existing one, but very few times does one come along that is actually BETTER.
In order to be better, your product or service has to be completely revolutionary. Sure, you could just slap a different label on something that's already been done, but that doesn't mean it's better – it just means you are different.
ReverseFX went way beyond different; it went way beyond better – it went straight to revolutionary. Not only was ReverseFX designed to look at the human body and a genetic response and its immune response as a whole – it was designed to balance all of those things as a myriad of complex systems married together and connected across the entire body. Every time you modify, activate, stimulate, suppress, or shut off one function of the human body – its effects will trickle down into the rest of the systems married to it through the whole.
ReverseFX took every one of these pathways and accounted for it to help the body achieve a perfect homeostatic balancing act of health, no matter which body system is out of balance. We don't do it through tricking it, forcing it, suppressing it. They key is found in the balancing of these bodily systems simultaneously creating total synergy. ReverseFX allows the body to return to its original state. Rewinding the clock and reverse engineering up to 10,000 genes.
ReverseFX took into account every single one of these genes and the cascading effect they have on the body to co-modulate their activity
There is never a day when you aren't exposed to environmental toxins, pathogens, viruses, bacteria, allergies, inflammation, etc.
Did you know the body has a unique way that it identifies foreign pathogens that helps distinguish friend from foe? Did you know that our immune system overrides virtually all other bodily systems?
Some of the most extensive problems the immune system can face are knowing what to attack/defend, and even more importantly - when to shut off. After an immune insult, these problems become the most significant hurdles to health, and that's where ReverseFX comes in. ReverseFX assists the body in the proper recognition of stealth invaders and in the identification of self-versus non-self.
This allows your immune system to mount an attack on anything foreign without an excess prolonged proinflammatory response.
Glycoimmunology encompasses bonded sugar molecules known as monosaccharides, polysaccharides, or oligosaccharides etc., which are basically carbohydrate-based structures also known as Glycans, all of which are intimately involved in Glycoimmunology. In fact, the loss of any component of these bonded sugar molecules can result in dire consequences and incompatibility with life itself.
Changes in the patterns of glycans (sugar chains) may lead to significant alterations in immune pathway signaling, as these glycans are important sugars that serve as the first contact point of cell-cell, but also host-pathogen interactions.
Glycans are essential biomolecules for energy storage, system regulatory purposes, and play an essential role in various immune and inflammatory diseases. Their diversity exceeds that even of DNA, with up to 25,000 genes, RNA, with approximately 360,000 mRNA, as every known cell is covered in glycans (sugars) which is as essential to life as a genome. Also, their structures exceed by orders of magnitude the number of the proteins encoded by our genome, which can be up to 400,000 proteins. This makes glycoimmunology quintessentially supreme is all things health. Interactions include the discrimination of self and non-self, antibody recognition, pathogen binding, modulation of immunity, infectious disease, inflammation, the binding of the hemagglutinin proteins, recognition of sialic acids, glycosaminoglycan synthesis, metastasis, cell adhesion, cell–cell signaling, intracellular transport, elimination of xenobiotics, sphingolipid metabolism, and more! Glycan patterns initiate immune reactions and virtually all cell surface receptors are glycoproteins. Glycan structures respond to environmental stimuli ranging from pH, ionic strength, hormonal stimulation, to inflammation, which aid in distinguishing health from disease, or self vs. non-self.
Glycoimmunology is the latest field of research in which the immune system uses specialized sugars in order to not only properly power itself but ensure that its functions are carried out properly. Foreign invaders can also reverse-hijack this and "hide" themselves with acidic sugars – but the makers of ReverseFX have taken this into account to help de-cloak these stealth pathogens that try to hide from the body's glycoimmunology functions that are normally utilized, giving your body and the immune system the edge over invaders and pathogens.
MANNOSE BINDING LECTIN
Mannose Binding Lectin plays an important role in the body's immune response by attaching to foreign invaders such as bacteria, viruses, or fungus and turns on the complement system. The complement system is a group of immune system proteins that work together to destroy foreign invaders (pathogens), trigger inflammation, and remove debris from cells and tissues. Mannose-binding lectin can also stimulate special immune cells to engulf and break down the attached pathogen. Studies show that up to 50% of individuals in some populations are affected by mannose-binding lectin deficiency. This leads to a complement deficiency, to which only 10% are identified. In other words, up to 90% of affected individuals have a propensity towards a malfunctioning immune system through MBL-D and complement deficiency. [Emphasis added]
Clathrin is a coated vesicle which forms the ancient triskelion, otherwise known as the Golden Spiral of Life. It transports cargo, allows cells to communicate, transfers nutrients, imports signaling receptors, and mediates an immune response after sampling the extracellular world. It also helps to clean up the cellular debris left by tissue inflammation. This clathrin endocytic (taking in of matter) pathway can be hijacked by viruses and other pathogens in order to gain entry to the cell during infection. Think of clathrin as the “propeller” of electromagnetic energy itself to which many proteins found in the body form the exact same geometry, which was shown with the HIV-1 virus in one of the previous slides. Clathrin also contributes to the stabilization of cellular division by acting as an inter-microtubule bridge. The M6PR, which mediates clathrin endocytosis, requires mannose, or the “Manna”.
Microtubules are involved in cell structure, the cilia, or cellular antenna, transportation and movement via motor proteins, vesicle trafficking (Clathrin), cellular division (by mitosis and meiosis), regulation of levels of key G-protein-coupled-receptor signaling channels, focal adhesion involving the Extra Cellular Matrix, development of the nervous system, gene expression, signal transduction, and are organized by microtubule organizing centers (MTOCs). Microtubules are also involved with Orchestrated objective reduction – a hypothesis explaining consciousness. Microtubules can act as substrates for motor proteins that are involved in important cellular functions such as energy fluctuations and movement. Some viruses, including retroviruses, that require access to the nucleus to replicate their genomes attach to motor proteins, which directly involve microtubules and clathrin.
ReverseFX also helps to support proper microtubule function so that foreign invaders cannot hijack your waking reality by sneaking in through the "antennas" to the quantum realm. Microtubules funnel your waking reality from "probability" to "actuality," – and foreign invaders can sneak in through these antennas and input their "signal" to attach themselves to the host.
ReverseFX helps to properly control this consciousness gateway to assure that only the signal of "YOU" is broadcast and picked up by your body – and not the static, noise, and foreign signals of pathogens. Reverse FX also specifically utilized "glycoimmunology" to be on the utmost frontier of immune-hacking.
The process of cell division begins upon the moment of conception when a huge flash occurs, known as a zinc spark, thus kick starting life itself as we know it. This zinc release closely follows calcium voltage signaling and is necessary for cell cycle division. Altering the natural pattern of calcium signaling in the fertilized egg can have long-term effects on gene expression in the embryo and on offspring development. Zinc has a prominent role during human egg activation and cellular division. Shilajit provides the body with up to 70 bound trace minerals which assists in the regulation of proper oocyte meiosis.
During cell division, microtubules mediate the separation of chromosomes into the two daughter cells. Numerous proteins are involved in regulating the complex processes in cell division, and kinases (start switch) and phosphatases (stop switch) are the primary regulators. Protein phosphatase 2A (PP2A) plays a critical role in the regulation of the cell cycle and is a master regulator. If all roads lead to Rome, then all roads also lead to PP2A. The most important kinase are Cyclin-dependent kinase (Cdk), Polo-like kinase (Plk), and Aurora kinase. The function of these genes ultimately impacts a gene called P53, the Guardian of the genome. The Ubiquitin Proteasome System (UPS) is also a major regulator of cell division by assisting in cell cycle progression and programmed protein destruction in human cells (Apoptosis).
THE UBIQUITIN PROTOSEOME SYSTEM
The Ubiquitin/Proteasome System (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. The UPS participates in a wide array of biological functions such as cell cycle and division, immune response and inflammation, viral infection, antigen processing and presentation, endocytosis (Clathrin), modulation of cell surface receptors, ion channels, neural and muscular degeneration, protein degradation, protein sorting, protein folding, DNA repair, apoptosis, signal transduction, response to stress, and activation or inactivation of NF-κB, a major pro-inflammatory cytokine. The UPS is a key regulator of the DNA damage response and the Nrf2 pathway preventing the inappropriate activation of cellular stress responses.
The UPS serves as a “quality-control system” that rapidly eliminates misfolded or damaged proteins whose accumulation would interfere with normal cell function and viability. The UPS has an important role in immunity and inflammation. The UPR is key in the control of lipid and energy metabolism, innate immunity and cell differentiation.
The UPS serves as a quality-control system that rapidly eliminates misfolded or damaged proteins whose accumulation would interfere with normal cell function and viability. Heat Shock Proteins (HSPs) are the master regulators of protein degradation that provide protection against misfolded or damaged proteins. Heat shock proteins (HSPs) have shown to possess the capacity of inducing lasting protective immune responses and immune tolerance. The function of the UPS and HSPs also incorporate The Unfolded Protein Response (UPR) which has an important role in immunity and inflammation. The UPR is key in the control of lipid and energy metabolism, innate immunity and cell differentiation.
Apoptosis is a Greek word meaning “falling off”. If cells are no longer needed, they commit suicide by activating an intracellular death program. A cell that undergoes apoptosis dies neatly, without damaging its neighbors. So apoptosis is a form of programmed cell death, or “cellular suicide.” It is different from necrosis, in which cells die due to injury. Apoptosis is an orderly process in which the cell’s contents are packaged into small packets of membrane for “garbage collection” by immune cells. Apoptosis removes cells during development, eliminates potentially cancerous and virus-infected cells, and maintains balance in the body. Certain pathogens have also developed ways in which to hijack these processes. The caspase cascade is a series of steps that results in the self-destruction of cells (apoptosis) when they are not needed. The Executioner gene, Caspase-3, and BCL2 Apoptosis Regulator are a few key genes involved.
Pathogens will also hijack Caspase-3, also known as "Death's Scythe" – the built-in mechanism to signal self-destruction when a cell becomes infected or takes on an abnormal shape, function, or lifespan. Pathogens, diseases, and mRNA responses can "shut off" the "kill switch" signaled by Caspase 3 to prolong the cell's life enough to spread more pathogens or divide into more pathogenic cells down the line. Inflammation is the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation, and acts by removing harmful stimuli and initiating the healing process.
Cell death plays an important role in the regulation of inflammation and may be the result of inflammation. The maintenance of tissue homeostasis necessitates both the recognition and removal of invading pathogens as well as the clearance of dying cells. The principal event that leads to inflammatory disease is cell damage, induced by a myriad of environmental factors. Cell damage means leakage of cell contents into the adjacent tissues. Neutrophil apoptosis may represent an important event in the control of inflammation. Removal of neutrophils from the inflammatory site is of paramount importance for cessation of inflammation. In host defense, programmed cell death can act in a protective manner; the death of infected cells may reduce infections, separate uninfected neighboring cells, and alert the host through danger signals and inflammatory mediators.
Viruses are master molecular manipulators, and evolved to thrive and survive in all species. Key to their continuing success has been the ability to subvert host cell defense systems to ensure viral survival and replication. Amongst the diverse arsenal of defense mechanisms deployed by multicellular hosts are those that rely on rapid activation of programmed cell death in order to trigger premature cell death of infected host cells. Apoptosis of an infected host cell has been identified as a powerful mechanism to curtail viral spread, and consequently, viruses have evolved sophisticated molecular strategies to subvert these host cell defenses.
The innate immune system is first line of defense against anything foreign, including invading stealth pathogens. This defense system enacts the complement cascade to promote identification and removal of foreign substances. Inflammation is one of the first responses of the immune system to infection, which is not a bad thing. The issue becomes when that inflammatory signal is left on for too long, thus leading to tissue damage! Pattern Recognition Receptors (PRRs) such as Toll like receptors (TLRs), C-type lectin receptors (CLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs), assist in distinguishing self from non-self and identifying pathogen-associated molecular patterns (PAMPs) which then release these inflammatory mediators (TNF, IL-6, IL-1, ect). This process "tags" pathogens for amelioration. Naturally, many pathogens have evolved mechanisms for immune evasion, in part, by mimicking host cells so the immune system does not recognize them as foreign, which brings us back to importance of Glycoimmunology. Within the Innate/Inflammatory response systems are CEACAM1 and Annexin genes. CEACAM1 controls the initiation of the modulation of innate and adaptive immune responses, while Annexin controls the “shut off” switch when inflammation has served its purpose. SLC2A3, which transports mannose, fucose (Bladderwrack), and ascorbate (Vitamin C), assists in the regulation of CEACAM1.
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends in part on the adaptive immune system, which remembers previous encounters with specific pathogens and destroys them when they attack again. Adaptive immune responses, however, are slow to develop on first exposure to a new pathogen; it can therefore take a week or so before the responses are effective. By contrast, during the first critical hours and days of exposure to a new pathogen, we rely on our innate immune system to protect us from infection.
SLC2A3 transports mannose, fucose (Bladderwrack), and ascorbate (Vitamin C), assists in the regulation of the top regulatory genes involved with innate immunity. GLUT3, otherwise known as SLC2A3, participates in immune and inflammatory responses and is critical for host defense. GLUT3 provides cellular fuel for the immune response, and high levels allows the cell to compete with pathogens for glycans, or sugars. Deletion of glucose transporter GLUT3/SLC2A3 interferes with mitochondrial metabolism, induces calcium overload, and glutamate excitotoxicity. GLUT3 plays an essential role in energy metabolism and AMPK activation. GLUT3 also impacts the function of cAMP-response element binding protein (CREB), both of which are important for brain function. By increasing surface expression of GLUT3, human macrophages obtain the cellular energy needed to enhance immune functions.
FC Receptors are found on cell surface of natural killer cells, macrophages, neutrophils, and mast cells, for example. They contribute to the protective functions of the immune system through the binding to antibodies that are attached to infected cells or invading pathogens. Some viruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection. Fc receptors regulate antibodies such as IgG, IgA, IgE, IgM which assist in helping identify and eliminate pathogens, allergic reactions, and initiate phagocytosis (a major mechanism used to remove pathogens and cell debris). Fc receptors may be regulated by targeting two main genes: Spleen Tyrosine Kinase (SYK) and SHP-1 (PTPN6).
Antibodies combine chemically with substances which the body recognizes as alien, such as bacteria, viruses, and foreign substances in the blood.
Fc receptors help to control immunity which is essential for appropriate responses to infections and prevention of chronic inflammation. Motifs, termed “ITAMs” and “ITIMs” for immunoreceptor tyrosinebased activation (or inhibitory) motifs, provide the basis for two opposed signaling modules that duel for control of cellular activation within the immune system. Modulation of SRC tyrosine kinase, through the ITIM/ITAM motifs helps to regulate Fc receptors in addition to modulation of spleen tyrosine kinase and shp-1.
ZAP70 & Spleen Tyrosine Kinase (SYK) are expressed on B and T cells respectively and are essential regulators of the lymphatic system. Syk plays also a crucial role in the innate immune response to fungal, bacterial, and viral pathogens with roles also found in the intestinal immune response. Research shows that Syk inhibition might aid in the regulation of autoimmune diseases with regulation of several biological processes including innate and adaptive immunity. Syk also regulates the NLRP3 inflammasome, NF-kappa-B, chemokines, and cytokines in presence of pathogens. It also assists in mast cells activation, macrophage activation, P-selectin, and recruitment of leukocytes to inflammatory sites. Upon neutrophil activation, CEACAM1 negatively regulates IL1B production by recruiting PTPN6 (SHP-1) to what’s known as the SYK-TLR4- CEACAM1 complex, which dephosphorylates SYK, thus reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome.
ZAP70 directs the development of and turns on (activates) immune system cells called T cells. T cells identify foreign substances and defend the body against infection. It plays an essential role in regulation of the adaptive immune response by regulating both the on and off switch of T-cells. These include cytotoxic T cells (CD8+ T cells), whose functions include destroying cells infected by viruses. The ZAP70 gene is also involved in the activation of helper T cells (CD4+ T cells). These cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.
Piezoelectricity is the electric charge that accumulates biological matter such as bone, DNA and various proteins. Piezo ion channels link mechanical forces to biological signals in mechanotransduction. Again, Piezo converts mechanical signals into electrical or chemical signals, which incorporates physiological processes in the body, including perception or awareness, touch, balance, and hearing. Piezo genes play a key role in blood vessel formation and vascular structure in both development and adult physiology. A malfunction of Piezo leads to cellular dehydration, increased red cell trapping in the spleen, swelling of body parts, functional defects of the lymphatic system, and recurrent local infections.
Also involved with Piezoelectric signaling are motor proteins called Myosins, which are also involved with microtubules. Myosin motor proteins have actin binding properties and possess kinetic energy transduction. Rho kinase (ROCK) kinases act as master regulators of myosin II and have a major impact on energy transduction through Piezo channels. Abnormal activation of the Rho/ROCK pathway has been observed in various disorders of the central nervous system. Inhibition of ROCK results in accelerated regeneration and enhanced functional recovery.
CONTROL THE MASTER SWITCHES
ReverseFX helps to normalize the feedback loop of the immune/inflammatory responses in the body. Inflammation is a defense mechanism that is vital to health. However, uncontrolled acute inflammation may become chronic, contributing to various chronic inflammatory diseases and unwanted cytokine storms.
ReverseFX was designed to enhance the proper immune/inflammatory response after insult and injury from environmental factors that often lead to adverse health events.