The untold benefits of Nattokinase in ReverseFX

Aside from what you may already know about Nattokinase and its use in assisting the body to help thin the blood in order to help to break up blood clots, let me also share some REALLY POWERFUL information about it.

First, Nattokinase is an enzyme that comes from a Japanese food called natto. Natto is made from boiled soybeans that have been fermented with a type of bacteria.

So Natto is from Soy.

Insert Spermidine….

Where is Spermidine derived from?

Two highest sources:

  • Wheat germ 243 mg/kg
  • Soybean, dried 207 mg/kg 

So Natto (soy) falls into the second highest category for spermidine sourcing.

What is Spermidine? 

The compound spermidine was first found in semen which accounts for its rather alarming name. Don’t get excited! Or, do…

Spermidine preserves mitochondrial function, exhibits anti-inflammatory properties, has prominent cardioprotective and neuroprotective effects, and stimulates anticancer immunosurveillance.

Spermidine is crucial in the process of cell renewal. As old cells die, other cannibalize them and put molecules to use in building new cells. As we get older our natural levels of spermidine decrease reducing the ability of our cells to renew and repair themselves which assists in expanding lifespan.

Voltage 

We are electrical beings living in an electrical universe.

Spermidine synchronizes an array of biological processes, (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential (electric charge) and controlling intracellular pH and volume.

There are many diseases related to ion channels. Channelopathies are a group of diseases caused by the dysfunction of ion channels. There are more than 400 genes that encode ion channels, found in all human cell types and are involved in almost all physiological processes.

 Autophagy

Spermidine is known to stimulate autophagy. A system that breaks down waste inside cells and recycles cellular components. 

It is an important quality control mechanism for the mitochondria, the powerhouses of our cells. Autophagy allows damaged or defective mitochondria to be broken down and disposed of. The disposal of mitochondria is more tightly controlled than was before believed.

Autophagy is the ultimate recycling system of the cell. The word comes from ancient Greek and means “eating of self”. Although its name might sound harmful, it appears to have longevity-promoting effects.

Autophagy is also one way our cells deal with energy shortages. For example, after a period of fasting, a body’s cells will respond by breaking down some of their organelles and proteins for energy. It functions as a survival mechanism when energy gets low.

It alleviates the issue of aggregated or misfolded proteins. It rids the cell of some types of damaged organelles, and it serves as an innate immune system defense against both viral and bacterial pathogens. 

It also seems to help protect against neurodegeneration, cancer, diabetes, heart, liver, and autoimmune disease. Autophagy can recycle aberrant mitochondria and can reduce unnecessary cell death in cells after they divide.

DNA

Spermidine can be found in all living organisms and is vital in the maintenance of cellular homeostasis. It is involved in multiple cellular processes such as gene transcription, translation, maintenance of genomic DNA stability, cell proliferation, and cell survival. It does this through modulation of Histone modifications and DNA methylation and may enhance epigenetic expression of key regulatory genes.

Immune

Emerging data suggest that spermidine exerts anti-inflammatory/immunoregulatory effects; it can protect mice from experimental autoimmune encephalomyelitis and psoriasis. 

Recently, spermidine was found to exert protective effects in an experimental model of multiple sclerosis (MS) to confer immunoregulatory properties on dendritic cells (DCs). 

In addition, under inflammatory conditions driven by interferon and Toll-like receptor stimulation spermidine suppresses the production of inflammatory tumor necrosis factor (TNF)-α and interleukin (IL)-6 cytokines. 

This has supported the concept that spermidine has a protective role in certain autoimmune diseases.

Spermidine Inhibits Proinflammatory Cytokine Synthesis 

The local production of proinflammatory cytokines mediates the host response to inflammation, infection, and injury, whereas an overexpression of these mediators can injure or kill the host.

Spermidine might counter regulate the innate immune response by downregulating the synthesis of potentially injurious cytokines.

It effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, MIP-1α, and MIP-1β.

In response to inflammatory stimuli, injured cells release spermine into the extracellular space, which is a sign of upregulated tissue repair.

Spermidine is also abundant within the gastrointestinal tract and might substantially contribute to gut immunity.

The human body is under constant exposure to foreign antigens, with the mucosal surfaces acting as major physical barriers for host protection. In the context of the intestinal tract, maintenance of a homeostatic environment is essential to stave off pathogens while remaining tolerant toward commensal bacteria and dietary antigens.

Fasting Mimic

Alternatively, caloric restriction mimetics (CRMs) like spermidine can be used to simulate the effects of fasting on the body without the negative side effects of hunger and lethargy that can accompany conventional fasting. Taking spermidine supplements tricks the body into a fasting state, thus inducing autophagy and protecting against age-related diseases including cancer, metabolic disease, heart disease and neurodegeneration. Spermidine can also increase longevity by preventing telomere shortening and stabilizing mitochondrial DNA, which both contribute to cellular aging.

Viral 

Additionally, it has the potential to be used against emerging viruses.

The body’s immune system defends against disease-causing pathogens by using innate responses that form the first line of defense, and adaptive responses that are engaged later. The innate immune system uses physical barriers like the skin and gut epithelium to prevent pathogens from entering the body, while the adaptive immune system uses leukocytes (white blood cells) as a cavalry to identify and eliminate pathogens in the body. 

 A side effect of this is increased inflammation, which while eliminating the pathogen, also causes symptoms such as swelling, heat, pain, loss of tissue function and severe pathology. This is evident in those currently suffering.

Autophagy works as part of both of these immune systems, clearing away pathogens and regulating inflammation.

 One study found that found that the “current infection” down-regulated cellular autophagy and spermidine levels by interfering with different metabolic pathways.

Targeting these pathways with administration of spermidine and other autophagy-inducing compounds maintained autophagy and reduced viral replication.

Mast Cell/Histamine

Spermidine has been shown to modulate the AOC1 Gene (Amine Oxidase Copper Containing 1).

This gene is heavily involved with innate immune system pathways. 

AOC1 encodes a metal-binding membrane glycoprotein that oxidatively removes amino groups from putrescine, histamine, and related compounds.

This gene catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. It is thought to play a role in the regulation of the female reproductive function. 

Histamine plays an important role in the immune response, an in particular allergic responses. In health, histamine is released from immune cells (known as mast cells) resident in the skin, gut or lungs when a pathogen or allergen is detected. Histamine is also related to Mast Cell Activation.

On study showed that spermidine inhibits mast cell secretion. 

Another study points out that spermidine is associated with mast cell secretory granules, are important for the correct maintenance of granule homeostasis (including appropriate storage of histamine) and suggest an important role for polyamines (spermidine) in regulating the complex machinery that leads to the formation of these organelles.

In addition, researchers have linked spermidine depletion in the cell with a 2.3-fold increase in intracellular histamine.

Mast cells participate both in the innate and adaptive immune response and are thereby considered an important component of the immune system. However, mast cells are best known for their implication in a large number of physio-pathological settings, including allergy, asthma, atherosclerosis, inflammatory arthritis, multiple sclerosis and cancer.

 Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation.

Spermine also stimulated the release of serotonin from mast cell granules, which themselves serve as important immune function regulators in M2 macrophage polarization.

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal.

Neuroprotective 

Studies also suggest it can improve cognition. Spermidine has a neuroprotective effect against neuron damage caused by inflammation and ischemia and oxidative stress. 

Spermidine is also food for the brain as it inhibits NMDA receptors which helps attenuate glutamate excitotoxicity. 

Spermidine significantly attenuated alterations in body weight, motor impairments, oxidative stress, neuroinflammatory markers, GABA, glutamate, catecholamines, adenosine, and their metabolites levels in striatum which may help to preserve higher-order brain functions.

Overall, findings in aging model organisms have suggested a promising role of spermidine in the promotion of brain and cognitive health. 

Spermidine (Natto) benefits:

• anti-inflammatory properties

• may modulate immune responses

• may enhance epigenetic expression 

• may delay aging

• may reduce cognitive decline

• might reduce the risk of cardiovascular disease and cancer

• supports cell metabolic regulation

• promotes immune system modulation

• increases immune system’s ability to identify harmful cells

What else does spermidine do? It achieves homeostasis!

1. Spermidine can improve the permeability of the blood-brain barrier.

2. Spermidine is involved in the aging process of organs. 

3. Spermidine is involved in the regulation of programmed cell death. (cancer)

4. Spermidine and spermine can prolong our lives and improve our health across various levels.

5. Spermidine can suppress cardiovascular age-related degradation by 10%. Which can mean an 8 extra years of life for people.

6. Spermidine delays the development of cancer in mice, even after administration of carcinogenic substances.

7. Spermidine slows down the breakdown of nerve structures and nerve functions. That is important when it comes to Parkinson’s, Alzheimer’s, Huntington’s and ALS.

8. The spermidine level in blood predicts the likelihood of us becoming ill and dying. The more spermidine, the better equipped against age-related illnesses and death due to age-related illnesses. Two scientific studies on humans have proven this. Consequently, Spermidine could add more healthy years to your life.

9. Spermidine boosts our health by inhibiting the EP300 gene. Just like an aspirin is supposed to do but without the side effects. Whereby Spermidine also has an anti-clotting (anticoagulant effect).

10. Spermidine stimulates cells to remove their waste more quickly, thereby enabling people to live longer.

11. Spermidine prolongs the life of our immune cells. As a result, their tests found that mice suffered less cell damage caused by aging. (According to the Austrian scientists Tobias Eisenberg and Frank Madeo.) 

Wow! That’s a TON of information about Nattokinase that you probably didn’t know. And, that’s just ONE ingredient of many found in ReverseFX.

ReverseFX is a masterfully formulated product like nothing else in the world!

Truly a [R]evolution is Self-Care!

Orders yours today!

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Sources:

https://www.cell.com/.../fulltext/S1471-4906(20)30214-3

https://en.wikipedia.org/wiki/Spermidine

https://www.sciencedirect.com/.../neuroscience/channelopathy 

https://rupress.org/.../Spermine-Inhibits-Proinflammatory...

https://www.sciencedirect.com/.../pii/S0091674920306370

https://www.longevity.technology/spermidine-and-covid-19.../

https://www.frontiersin.org/arti.../10.3389/fimmu.2017.00093

https://www.tandfonline.com/.../10.../15548627.2019.1698210

https://pathcards.genecards.org/Card/innate_immune_system

https://www.genecards.org/cgi-bin/carddisp.pl?gene=AOC1

https://pubmed.ncbi.nlm.nih.gov/1599509/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994821/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229744

https://www.frontiersin.org/.../fphar.2021.746910/full

https://pubmed.ncbi.nlm.nih.gov/26078029/

https://alzres.biomedcentral.com/.../s13195-019-0484-1

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