The precision synergy of ReverseFX and the lungs

ReverseFX helps to modulate one of the most important genes in our body. This gene is the most common life-threatening genetic disease of Caucasians. 

It’s an ion channel that is required for the normal function of epithelia lining the airways, intestinal tract as well as ducts in the pancreas and sweat glands and is also involved with male infertility.

It functions as a channel across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. 

In reality, this gene helps regulate MUCH MORE than just the function of our lungs!

It transports negatively charged particles called chloride ions into and out of cells.

The transport of chloride ions helps control the movement of water in tissues, which is necessary for the production of thin, freely flowing mucus. Mucus is a slippery substance that lubricates and protects the lining of the airways, digestive system, reproductive system, and other organs and tissues.

Regulation of Bicarbonate

It also regulates numerous other pathways, such as the transport of bicarbonate (HCO3−), and Iodine (thiocyanate), immune cells, and the metabolism of lipids. 

It influences the pH homeostasis of airway surface liquid and thus mucus clearance as well as innate immunity leading to chronic infection and inflammation.

Bicarbonate (HCO3−) plays a major role in airway surface liquid pH homeostasis and therefore in the innate immunity system and mucus viscosity. HCO3− secretion, and host defense have been demonstrated in the lungs and support that HCO3− is an essential component to maintain a normal airway surface liquid pH of ~7.1 and promote a competent innate immunity, such as antimicrobial activity, in order to protect the lungs against infections.

Moreover, HCO3− is essential to inhibiting bacterial growth, airway colonization, and biofilm formation.

Mucosal clearing is complex and its effectiveness depends on the mucus that traps inhaled particles or pathogens, on the cilia whose beating removes secretions from the lungs, and on the periciliary layer that protects the epithelium against dehydration and allows the cilia to beat. As this gene is also expressed in the mucin granules of airway epithelial cells that contribute to mucus viscosity, it regulates mucus flow as well as mucosal clearing which is key in a functioning innate immune defense. 

Mucus viscosity depends on the mucins that require bicarbonate (HCO3−). During the process of mucin release, calcium (Ca2+) and hydrogen (H+) ions must be removed to enable the negatively charged mucins to expand by up to 1000-fold and form mucus gel networks. HCO3− is critical for sequestering Ca2+ and H+ to allow normal expansion of mucins. These changes lead to a subsequent influx of water and the rehydration of the lung, and other organs. 

Regulation of Electrolyte Balance

It also regulates other ion channels, particularly the epithelial sodium (Na+) channel (ENaC) that plays the central role in salt absorption which also contributes to the balance of water and salt in the body.

These epithelial sodium (Na+) channels (ENaC) play an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. They controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. They also play a role in taste perception.

In addition to being implicated in diseases where fluid balance across epithelial membranes is perturbed, including pulmonary edema, cystic fibrosis, COPD and THE CURRENT VIRUS, proteolyzed forms of ENaC function as the human salt taste receptor.

Regulation of the Plumbing System

This gene also helps regulate aquaporin channels (plumbing system). Dehydration contributes to mucus hyper viscosity and restricts cilia function as well as mucus clearing. Modulators of this gene improve ion channel function and therefore airway hydration and the clearing of pathogens that have been trapped by the mucus.

Regulation of Glutathione

This also regulates glutathione flux in the control of oxidative stress in the airways. Glutathione is considered to be one of the body’s most important intra- and extracellular antioxidants, providing protection against exposure to high levels of reactive oxygen species, to tissues such as the lung. Glutathione has also been implicated in the regulation of inflammation and the immune response, with GSH deficiency exacerbating inflammation and damage of the airways. This contributes to maintaining normal airway physiology by modifying mucus viscosity.

An imbalance between antioxidants leads to oxidative stress. Lung injury is characterized by an exaggerated neutrophil-dominated inflammation that is ineffective to clear bacterial infections and the oxidative stress. The loss of this functional gene reduces the glutathione.

Regulation of The Golden Spiral

This gene is removed from the cell surface by clathrin mediated endocytosis.

Clathrin is used to build small vesicles in order to transport molecules and forms a triskelion shape within the cell. 

Triskelions are the bases for what’s called Archimedean spirals. 

Archimedean spirals form the “Golden spiral of Life”, or “Fibonacci sequence.”

Clathrin allows cells to communicate, to transfer nutrients, to import signaling receptors, to mediate an immune response after sampling the extracellular world, and to clean up the cell debris left by tissue inflammation. The endocytic pathway can be hijacked by viruses and other pathogens in order to gain entry to the cell during infection.

Mannose 6-Phosphate Receptors regulate the formation of Clathrin-coated Vesicles.

Therefore, Mannose controls the Golden Spiral of Life and Clathrin mediated endocytosis helps regulate this gene.

Relationship with Immune Cells

Beside its role in innate immunity related to ion transport, this gene is also expressed in immune cells, including macrophages and neutrophils. These help maintain immunological and physiological homeostasis in the lungs and are the front line of cellular defense against pathogens that were not eliminated by the mechanical defenses of the airways.

They also allow inflammatory response initiation and recruitment of activated neutrophils and secretion of cytokines and chemokines, such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-α, as well as AA metabolites (leukotrienes and prostaglandins). Airway inflammation is therefore characterized by increased levels of pro-inflammatory cytokines and chemokines, as well as a massive influx of neutrophils that, through the release of ROS (oxidative stress) cause respiratory epithelium damage and progressive lung injury.

This gene can actually also regulate the signaling of receptors involved in the recognition of microbial stimuli called pathogen-associated molecular patterns (PAMPs). 

Toll-like receptors (TLRs), a member of the pattern recognition receptors (PRR), partially mediate the inflammation by activating the nuclear factor (NF)-κB, which governs a molecular pathway that induces the production of inflammatory mediators. 

Disruption of these mechanisms leads to secondary necrosis of accumulating apoptotic cells, release of necrotic cell debris called damage-associated molecular patterns (DAMPs), and uncontrolled activation of the innate immune system.

Thus, the inflammation is self-sustaining and causes tissue damage.

This gene helps to regulate all of these inflammatory signals and uncontrolled activation of the immune system.

This gene also contributes to lysosomal acidification and its dysfunction prevents phagolysosome acidification, thereby providing an environment favorable to pathogen replication.

Acidosis and our Immune System

It has been said that disease can’t live in a high alkaline environment. 

This gene helps to regulate pH and acidosis. Acidosis is a condition in which there is too much acid in the body fluids.

At the chemical level, pH stands for potential of hydrogen. pH is a measure of hydrogen ion concentration; a measure of the acidity or alkalinity.

Acidosis is now being shown to be related to an over-taxed immune system, for it is known that in sickness, the human body is always acidic. The orthodox establishment considers acidosis to be a symptom of whatever disease happens to be present, instead of considering that acidosis could be the root cause of multiple disease states.

Acidosis is related to inflammation, which is a natural protective response by the body. It can be beneficial in some instances as with a cut finger – the inflammatory process helps to block harmful microorganisms and repair the wound – but lasting inflammation can be very harmful to the body. Chronic inflammation produces continual free radicals that can potentially damage DNA, speeding the aging process and contributing to disease.

Unless the body’s pH level is slightly alkaline, the body cannot heal itself. You cannot improve your general health until pH levels are above 7. Most all drugs and medications (over the counter & prescription) are toxic and can cause the pH to be acidic as well. Acid decreases the body’s ability to repair damaged cells, decreases the ability to get rid of heavy metals and it makes the body more susceptible to fatigue and illness. 

Everything pivots on a balanced pH. When bodily pH drops, enzymes are deactivated, digestion is interrupted; vital nutrients are not effectively assimilated. Disease cannot survive in an alkaline state; however, in a low oxygen/low pH (acidic) state, viruses, bacteria, yeast, mold, fungus, Candida and Cancer cells all thrive.

Acid-sensing ion channels (ASIC)

Acid-sensing ion channels (ASIC) are a family of ion channels that are widely expressed in neurons of the central and peripheral nervous system. Among their related pathways are Ion channel transport and CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF).

They function in learning, pain transduction, touch sensation, and development of memory and fear. ASICs are potential drug targets due to their involvement in pathological states such as retinal damage, seizures, and ischemic brain injury.

They are involved in glutamate excitotoxicity and calcium overload which are detrimental to health.

The role of the ASIC is to sense reduced levels of extracellular pH and result in a response or signal from the neuron.

In sensory neurons they help mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue.

These channels are inhibited by diuretic amiloride. Amiloride is a type of diuretic (water pill) that helps prevent your body from losing too much potassium. The reason these “water pills” work is by helping to regulate the balance between water and salt, which is EXACTLY what the gene we are discussing here does!

There are some other factors that can play a role on the regulation of the ASICs. The presence of matured N-linked glycans on the surface of the channel is said to allow the channel to preferentially traffic.

N-linked glycans are related to Glycoimmunology to which Mannose, N-Acetylglucosamine, and Fucose (Bladderwrack) are heavily involved. 

N-linked glycosylation, is the attachment of an oligosaccharide, a carbohydrate consisting of several sugar molecules (Glycoimmunology), sometimes also referred to as glycan, to a nitrogen atom (the amide nitrogen of an asparagine (Asn) residue of a protein), in a process called N-glycosylation, studied in biochemistry.

So just what is this gene we’ve been discussing?

It’s the CFTR gene (cystic fibrosis transmembrane conductance regulator)

https://www.mdpi.com/2073-4409/10/11/2844/htm

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One of the reasons ReverseFX is so powerful is because it contains compounds found in nature to help modulate CFTR.

So what are these ingredients?

CFTR (cystic fibrosis transmembrane conductance regulator) Compounds:

  • Resveratrol 
  • Tannic acid (Pomegranate, Resveratrol, Prunella vulgaris)
  • Kudzu (a form of genistein)
  • Nattokinase (a form of genistein)
  • Citric acid
  • Apigenin (Ashwagandha)
  • Chloride ion

If you’re looking to help your lungs (and soooo much more) then you need ReverseFX is your arsenal!

ReverseFX is a [R]evolution is self-care that targets up to 10,000 genes in the body, thus restoring your immune system back to its divine template, before dis-ease and malady became the “new normal.”

www.reversefx.com

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Sources:

https://medlineplus.gov/genetics/gene/cftr/

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CFTR

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC156066/

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1964799/

https://commerce.bio-rad.com/en-us/prime-pcr-assays/pathway/wtcftr-delta508-traffic-clathrin-coated-vesicles-formation-norm-cf

https://www.mdpi.com/2073-4409/10/11/2844/htm

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCNN1

https://en.wikipedia.org/wiki/Epithelial_sodium_channel

https://d3i71xaburhd42.cloudfront.net/1a86f2f25f91d773d62601df4aa189b35dcb0eb3/8-Figure4-1.png

https://en.wikipedia.org/wiki/Clathrin

https://en.wikipedia.org/wiki/Triskelion

https://en.wikipedia.org/wiki/Archimedean_spiral

https://en.wikipedia.org/wiki/Golden_spiral

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2139777/

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ASIC3

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ASIC1

https://en.wikipedia.org/wiki/Acid-sensing_ion_channel

https://en.wikipedia.org/wiki/N-linked_glycosylation

https://www.frontiersin.org/articles/10.3389/fcell.2021.742891/full

https://www.frontiersin.org/files/Articles/742891/fcell-09-742891-HTML-r1/image_m/fcell-09-742891-g001.jpg

https://www.mdpi.com/1422-0067/21/9/3133/htm

https://link.springer.com/article/10.1007/s00018-020-03540-9

https://www.intechopen.com/chapters/71727

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4828912/

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CFTR&keywords=cftr#drugs_compounds

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