The word "Laman" means "House/Home."
The alias for the MAN2B1 Gene is LAMAN. This gene involves what's known as the Lysosome.
The MAN2B1 gene provides instructions for making the enzyme alpha-mannosidase.
This enzyme works in the lysosomes, which are compartments that digest and recycle materials in the cell.
Within lysosomes, the enzyme helps break down complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins).
In particular, alpha-mannosidase helps break down oligosaccharides containing a sugar molecule called mannose.
Lysosomes act as the waste disposal system of the cell. They break down excess or worn-out cell parts and also may be used to destroy invading viruses and bacteria.
So the lysosomes help provide a function against infection, and the cell will often engorge a bacterium and put it into its lysosome for destruction.
It's an important organelle that has function against infection. Mannose is required for proper lysosome function.
Enzymes destined for a lysosome are specifically tagged with the molecule mannose 6-phosphate. Mannose assists the lysosome (garbage disposal unit) to break down virus particles or bacteria in phagocytosis of macrophages.
As the endpoint of endocytosis, the lysosome also acts as a safeguard in preventing pathogens from being able to reach the cytoplasm before being degraded.
Pathogens often hijack endocytotic pathways such as pinocytosis in order to gain entry into the cell.
The lysosome prevents easy entry into the cell by hydrolyzing the biomolecules of pathogens necessary for their replication strategies; reduced Lysosomal activity results in an increase in viral infectivity. Viruses hijack lysosomes to exit cells.
Certain immune system cells rely on lysosomes to degrade proteins into short pieces that help trigger other immune cells to respond. Researchers found that the viruses can deactivate this disease-fighting function of the lysosome.
Dysfunctional lysosome activity is also heavily implicated in the biology of aging, and age-related diseases such as Alzheimer's, Parkinson's, and cardiovascular disease.
Aside from Mannose, the lysosome also requires Glucosamine, Chondroitin sulfate, and Heparin (Nattokinase) to maintain its functionality. Glucosamine, Chondroitin sulfate, and Heparin (Nattokinase) are involved with Glycosaminoglycan (GAG) synthesis.
Studies show that abnormal GAG synthesis can cause an abnormal amount of GAGs to accumulate in the lysosome.
Kudzu root contains active compounds similar to Genestein which assist the lysosome in recyling GAGs.
Salvia miltiorrhiza (Dan shen) also helps restore lysosomal cathepsin activities which is attributed to enhanced autophagosome-lysosome fusion.
Understanding this pathway, through which replicated viral particles are able to leave infected cells (shedding) and spread through the body, could be vital to stopping the transmission of viruses.
ReverseFX contains compounds that have been shown in research to impact the lysosome (waste disposal unit).
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https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAN2B1... https://medlineplus.gov/genetics/gene/man2b1/ https://en.m.wiktionary.org/wiki/laman https://en.m.wikipedia.org/wiki/Lysosome https://www.nih.gov/.../coronaviruses-hijack-lysosomes... https://www.drugtargetreview.com/.../lysosomes-key-to.../ https://www.karger.com/Article/FullText/490985 https://www.frontiersin.org/.../10.../fphar.2020.00351/full https://journals.sagepub.com/doi/10.1177/1559325820934227
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.