Remove toxic waste from the brain

The Glymphatic system (The Waste Clearance System in the Brain) is highly dependent on several factors to maintain proper brain function and help remove toxic waste.

The disruption of this system plays a crucial role in age-related changes of brain functions, as well as in the pathogenesis of neurovascular, neurodegenerative, neuro-inflammatory diseases, brain injury, and tumors.

Even symptoms related to C-vid long haulers can suffer neurological and psychiatric symptoms that range from loss of smell, headache, and brain fog, etc.

Cerebrospinal fluid (CSF)

The choroid plexus (CP) is responsible for the production of a large amount of the cerebrospinal fluid (CSF).

Although the first known observations of the CSF date back to Hippocrates (460–375 BCE) and later, to Galen (130–200 CE), its discovery is credited to Emanuel Swedenborg (1688–1772 CE), who, being a devoutly religious man, identified the CSF during his search for the seat of the soul.

His description of the CSF was of a "spirituous lymph."

Others have described it as a "highly gifted juice."

The glymphatic system serves as the brain's “front end” waste drainage pathway that includes a network for cerebrospinal fluid (CSF) transport.

The "Gatekeeper"

The "gatekeeper" and metabolic waste management system in the brain is Klotho/Clotho via the Choroid Plexus.

The choroid plexus looks for imbalances in CSF health and can activate a rapid response to brain emergencies.

When there’s trouble in the brain, the choroid plexus is one of the gatekeepers. Klotho/Clotho controls the brain–immune system interface in the choroid plexus. The choroid plexus mediates the production of cerebrospinal fluid (CSF).

CSF acts as a medium for a filtration system that facilitates the removal of metabolic waste from the brain. Klotho is a hormone secreted into human cerebrospinal fluid (CSF).

KLOTHO – the name of the gene comes from Klotho or Clotho, one of the Moirai, or Fates, in Greek mythology. They controlled the mother thread of life of every mortal from birth to death.

Studies showed that overexpression of Klotho in mice might extend their average life span between 19% and 31% compared to normal mice.

Reducing klotho within the choroid plexus triggers inflammation and enhanced activation of innate immune cells within the brain region.

The role of the choroid plexus in neuroinflammation continues to garner interest, including mechanisms for combatting infection.

During the course of infectious disease, cells of the choroid plexus can experience interactions with intruding pathogens, especially when the CP is used as a gateway for entry into the CNS.

THE CHOROID PLEXUS AS AN ENTRY GATE FOR PATHOGENS INTO THE CNS To prevent uncontrolled access of unwanted substances, including toxins, pharmacologically active agents, as well as pathogens to the CNS, the blood-cerebrospinal fluid barrier (BCSFB) employs several mechanisms to seal the blood from the CNS at the CP.

PATHOGEN-HOST CELL INTERACTIONS AT THE CHOROID PLEXUS Pathogens undergo extensive interactions with cells of the host organism, including immune cells and the cells comprising the CP.

Whether viral, bacterial, fungal, or parasitic, each pathogen is equipped with a unique set of outer or transmembrane structural proteins involved in physical interaction between the pathogen and the surface of host cells.

This physical interaction can then lead to the activation of mechanisms enabling pathogen invasion.

So...upregulating Klotho assists cerebrospinal fluid which in turn helps our glymphatic system remove waste.

Glyoimmunology

Glycosaminoglycan (GAG) distribution may contribute to the pattern of cerebrospinal fluid outflow.

Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix and has a MAJOR IMPACT on CSF/Klotho upregulation.

Mannose Mannose receptor expression located at blood-brain (perivascular), brain-cerebrospinal fluid (CSF) (meningeal), and CSF-blood (choroid plexus) interfaces supports a functional role of these cells in responding to external stimuli such as infection.

D-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation, diminishes the proinflammatory response, and boosted the antiinflammatory response from macrophages and microglia Neurological manifestations are common in patients with the "current" virus.

In fact, cerebrospinal fluid (CSF) leakage after nasal testing for "C" has also been reported!!!

Tight junction proteins and Aquaporin channels also play a role in relation to the Choroid Plexus and CSF. But, that is a topic for another day.

ReverseFX contains compounds that have been shown in research to assist the glymphatic system, choroid plexus, and CSF in the brain in order to enhance brain function.

Order yours here
www.reversefx.com

Sources:
https://www.frontiersin.org/.../fnins.2021.639140/full https://www.frontiersin.org/.../fnana.2021.665803/full https://www.pnas.org/content/115/48/E11388 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022081/ https://www.frontiersin.org/.../10.../fncel.2012.00034/full https://pubmed.ncbi.nlm.nih.gov/6633786/ https://journals.physiology.org/.../ajpcell.00137.2017 https://www.nature.com/articles/s41586-021-03710-0 https://pubmed.ncbi.nlm.nih.gov/15538754/ https://casereports.bmj.com/content/13/9/e237378 https://pubmed.ncbi.nlm.nih.gov/33249438/ https://onlinelibrary.wiley.com/doi/10.1002/ccr3.4597 https://jamanetwork.com/.../jamaotola.../fullarticle/2771362 https://www.pnas.org/content/118/44/e2107663118 https://watermark.silverchair.com/68-3-217.pdf https://pubmed.ncbi.nlm.nih.gov/22265655/

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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