January 22, 2022

Digestion, absorption, and gut health — ReverseFX

If you want to boost immunity, look to the gut. 70% of the immune system is located in the gut. Gut health is vital for physical and mental health, immunity, and more.

Much of the body’s immune response depends upon the gut and understanding its complexities and potential therapeutic targets is essential, particularly in times of stress and/or when risk of infection increases.

Why do people experience improvements in gut health with ReverseFX?

Let’s look at how it works…

Fats, carbohydrates, and proteins are broken down to small molecules - fatty acids, cholesterol, and glycerol, monosaccharides, and amino acids - within the lumen of the gastrointestinal tract and absorbed into the body principally through the small intestine. Movement of the final products of digestion out of the intestinal lumen is mediated by several of transporters. (See image)

https://reactome.org/PathwayBrowser/#/R-HSA-8963743&SEL=R-HSA-8963676&DTAB

Depicted in the image are 6 transporters:

SLC5A1

The SLC5A1 gene requires N-Acetylglucosamine (NAG) and Zinc for proper function.

This gene provides instructions for producing a protein called sodium/glucose cotransporter protein 1 (SGLT1). It spans the membrane of cells and moves (transports) two sugars called glucose and galactose from outside the cell to inside the cell.

Dan shen and Kudzu also support upstream pathways (Inwardly-Rectifying Potassium channels).

SLC2A5

This genes pathways works on signaling involved with fructose, NAD biosynthesis and steroid metabolism.

SLC2A5 is a fructose transporter responsible for fructose uptake by the small intestine and plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose.

Resveratrol has been shown to prevent high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats. Resveratrol also increases intracellular NAD+ levels through up regulation of the NAD+ synthetic enzyme nicotinamide mononucleotide adenylyltransferase (vitamin B3).

Licorice inhibits 5-alpha-reductase as well as zinc and riboflavin (vitamin B2).

As SIRT1 requires NAD+ as a substrate to perform its gene silencing function, higher NAD+ levels will enhance SIRT1 activity as well.

In addition, arginine, lysine and ornithine help SLC2A5 in upstream pathway support. (ButterflyFX)

N-acetyl cysteine (NAC) and Coenzyme Q10 also supports upstream pathways. (ButterflyFX)

SLC5A9

D-Mannose is essential for the function of SLC5A9. It is a Na+-dependent glucose transporter, which is a transporter for mannose. Eating apples has also been shown to target the function of this gene.

+/K+ ATPase inhibitors also work on upstream pathways to which Dan shen and Kudzu target.

SLC2A2

N-Acetylglucosamine (NAG) is also essential for the function of SLC2A2/GLUT2.

Zinc helps support upstream pathways in addition to arginine, lysine and ornithine. (ButterflyFX)

NPC1L1

NPC1L1 plays a critical role in the absorption of intestinal cholesterol and plays a critical role in regulating lipid metabolism. It also has the ability to transport alpha-tocopherol (vitamin E).

Sea buckthorn is rich in vitamin E.

The upstream regulator for NPC1L1 is CFTR, which is a MAJOR “hot spot” in the genome.

CFTR functions as a chloride channel and controls ion and water secretion, fluid homeostasis, and absorption in epithelial tissues. It plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens [emphasis added] and regulates bicarbonate secretion.

ACE2 expression and localization are regulated by CFTR

Resveratrol and Kudzu target CFTR. Minerals (chloride) also support CFTR.

Sodium bicarbonate's ability to neutralize acid helps. People commonly use sodium bicarbonate for indigestion.

SLC15A1

Peptide transporter 1 (PepT 1) also known as (SLC15A1) plays an important role in the uptake and digestion of dietary proteins. PepT 1 is a solute carrier for oligopeptides.

HMG-CoA reductase and ACE inhibitors target this gene.

Among them are Dan shen (big one), Oleanolic acid-Ursolic acid-Rosmarinic acid (all found in Prunella vulgaris), Resveratrol, Pomegranate, Ashwagandha, Ginger, Kudzu, and Sea buckthorn (folate) to name a few.

Phosphatidylcholine, magnesium, and manganese regulate the upstream pathways involved with SLC15A1.

Also, a C-type lectin domain sits upstream which binds sulfated glycosaminoglycans (GAGs).

Chondroitin sulfate, N-Acetylglucosamine (NAG), and Heparin (Nattokinase), and needed for GAGs.

Taurine assists in the function of these pathways as well as Coenzyme Q10 and Cannabidiol.

Supporting a healthy gut is a cornerstone of functional medicine and essential for strengthening immune responses and improving overall health. Focusing on modifiable lifestyle factors may optimize immune system function while supporting gut health. Such lifestyle modifications may include the following:

Therapeutic food plans such as the Mediterranean diet
Adequate sleep and sleep quality
Movement and exercise plans
Reduction of dietary triggers and toxic exposures
Stress management or transformation

As you can see we’ve done our homework so you don’t have to. If you are struggling with issues related to gut health ReverseFX has you covered.

In these interesting times it’s vital to and your family to optimize your health!

ReverseFX is available here

https://reversefx.com/collections/all

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sources:

https://medlineplus.gov/genetics/gene/slc5a1/

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC2A2

https://www.nature.com/articles/npre.2010.4421.1

https://pubmed.ncbi.nlm.nih.gov/23872130/

https://en.wikipedia.org/wiki/5%CE%B1-Reductase

https://pubmed.ncbi.nlm.nih.gov/30980598/

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC5A9

https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0035-1546131.pdf

https://en.wikipedia.org/wiki/GLUT2

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC2A2

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NPC1L1